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The preclinical studies were powered based on power calculations on the endpoints with highest variability (alanine aminotransferase and Col1 area %) in previous studies

GLP-1 (Glucagon-like peptide-1) agonists are medications that mimic the bodys natural hormones to regulate blood sugar and reduce appetite

Trial STEP 2 (Davies et al., Lancet 2021) Design Phase 3 / 68 weeks Population 1,210 adults with T2D and overweight or obesity Key result -9.6% body weight (2.4 mg) vs -3.4% placebo

In May 2022, tirzepatide also gained FDA approval for the treatment of adults with type 2 diabetes and obesity

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